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This means that CBD can decrease the amount of a medication that is destroyed by enzymes during the first pass through the liver. It may seem like this is only a small change, but Xanax is a very powerful drug. Xanax for Dogs – If you’re the dog owner that would rather lean towards a natural supplement to help treat your dog’s anxiety, go with CBD oil. Does CBD interact with Xanax, the popular drug for anxiety? CBD oil or CBD gummies from hemp or cannabis may cause a serious drug interaction. Xanax can provide relief within buy cbd oil bellwood al minutes of oral administration, with peak plasma concentration seen within 1 to 2 hours, which is a relatively faster onset than other anti-anxiety medications, like Ssris [25].